在 intron 18 中插入了 loxP 立场,随后在 exon 15 上游插入了带有 FRT-loxP 标记的诺卡因载体。Flp 重组酶剪除了选择性载体,使得 exons 15 到 18 由 loxP 立场相邻。接下来,Cre 重组酶去除掉了 15-18 位号的序列。参考文献:J:184591, J:184592

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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