设计了一种靶向载体,它包含一个位于序列上游的loxP位点,接着是一个由frt标签的诺卡因抗性基因(neo)区,随后是一个下游的loxP位点。通过Flp介导的重组,去除了neo基因 cassette,使得序列被标记为可翻转(floxed)。(来源:J:188152)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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