这种敲入株中,第14外显子的9个arginine被lysine(arginine替换为lysine,R->K)替换。靶向载体包含一个由loxP序列标记的R->K片段、FRT位点、PGK-neomycin cassette、另一个loxP位点以及另一个FRT位点。通过Flp介导的重组移除了neo cassette。(来源:J:184053)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
Insertion, Nucleotide substitutions
--
1
5
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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