插入PGK_EM7_PuDtk_bGHpA cassette导致了12号染色体(构建GRCm39)上一个381碱基对的缺失,起始位置在112,097,192,结束于112,097,573。这个缺失删除了该微小RNA的DNA序列。该 cassette 包含一个loxP位点,随后是F3位点,接着是PGK-puromycin-delta-tk cassette,再是另一个loxP位点,最后是FRT位点。(来源:J:174268)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count