插入PGK_EM7_PuDtk_bGHpA cassette导致了6号染色体(GRCm39构建)一段436碱基的缺失,起始位置在52,186,460,终止于52,186,896。这个缺失区域包含了微小RNA的DNA序列。该 cassette 包含一个loxP位点,随后是F3位点,接着是PGK-puromycin-delta-tk cassette,再是另一个loxP位点,最后是FRT位点。(来源:J:174268)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count