Tg(Lck-AVEN)1Zrng

This transgene contains a full-length cDNA encoding human caspase activation inhibitor (AVEN) inserted into the p1017 expression vector, which contains a 3.2 kb fragment of the mouse lymphocyte protein tyrosine kinase (Lck) gene that includes its thymocyte-specific proximal promoter through nucleotide +37 (relative to the transcription initiation site) upstream of the nearly full-length human growth hormone (GH1) gene; the insertion site is in the truncated first exon of GH1, which encodes the 5' UTR. (J:82809, J:132210)