通过Cre介导的重组,去除了Mir688tm1Mtm中的neo cassette和microRNA的茎环结构。qRT-PCR结果显示microRNA的缺失。在E11.5胚胎中未观察到β-galactosidase的表达,而在E18.5胚胎和成年大脑中有所表达。(引用: J:181752)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count