通过Cre介导的重组,去除了Mir688tm1Mtm中的neo cassette和microRNA的茎环结构。qRT-PCR结果显示microRNA的缺失。在E11.5胚胎中未观察到β-galactosidase的表达,而在E18.5胚胎和成年大脑中有所表达。(引用: J:181752)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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