通过Cre介导的重组,neo cassette和Mir205tm1Mtm的微小RNA茎环结构被移除。qRT-PCR结果显示微小RNA茎环确实丢失了。在E11.5时,胚胎前脑、咽弓和四肢中观察到了β-galactosidase表达,而在E18.5时,胚胎的心脏、皮肤和肾脏也显示出这种表达(引用号:J:181752)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
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--
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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