通过同源重组,将一个floxed倒置的MC1-neo cassette插入到exon 6上游,然后在exon 7下游插入了一个loxP位点。通过Cre介导的重组,去除了neo cassette和6、7号外显子。 Western blot结果显示,这个等位基因不表达全长蛋白,但检测到了C端片段的表达。(来源:J:181294)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部