在通过同源重组,一个被敲除的MC1-neo cassette被插入到exon 6上游,而后一个loxP位点被插入到exon 7的下游。随后,通过Cre介导的重组,neo cassette被移除,使得exons 6和7被标记为可翻转。(来源:J:181294)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count