在Mir34b的上游插入了loxP位点,而在Mir34c的下游则插入了一个带有3' loxP座的FRT引导的neo cassette。通过Cre介导的重组,neo cassette和这两个microRNA都被去除了。实时PCR证实了在小鼠胚胎成纤维细胞中,转录表达已不复存在。(来源:J:180692)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入,基因内删除
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7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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