在exon 4上游插入了一个新测序盒。在exon 5下游插入了一个带有3' loxP位点的FRT引导的neo测序盒。通过Cre介导的重组,去除了exons 4和5以及neo测序盒。 Western blot分析证实了在小鼠胚胎成纤维细胞和脑组织中没有蛋白质表达。(来源:J:180706)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
3
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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