人类链球菌毒素受体(Diphtheria Toxin Receptor, HBEGF)的cDNA序列为:包含一个内含子(IRE, 间隔序列),一个EYFP荧光报告基因,一个loxP位点,小鼠Ace(血管紧张素I转化酶,peptidyl-dipeptidase A 1)的启动子,cre重组酶基因,一个诺卡霉素抗性基因座,以及另一个loxP位点。这些元件被插入在起始密码子(ATG)之后,导致宿主基因的内源性翻译被阻断。在雄性生殖细胞中,通过cre重组酶的介导,去除了cre+neo基因座,未检测到YFP表达。(来源:J:180899)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入
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1
2
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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