将编码Cre重组酶的cDNA,带有牛的poly(A)序列和核定位信号(NLS),后面跟着Frt-flanked neo cassette,通过同源重组插入Cd207(角蛋白7)的第二个外显子。在验证了遗传传代后,通过与表达FLPe的实验鼠杂交,从该等位基因中删除了neo抗性元件。(来源:J:179630)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count