将编码Cre重组酶的cDNA,带有牛的poly(A)序列和核定位信号(NLS),后面跟着Frt-flanked neo cassette,通过同源重组插入Cd207(角蛋白7)的第二个外显子。在验证了遗传传代后,通过与表达FLPe的实验鼠杂交,从该等位基因中删除了neo抗性元件。(来源:J:179630)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
--
1
1
16

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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