Rgs18^m1H

The mutation was identified in a screen of the Harwell ENU mutant archive for mutations in this gene. The molecular lesion is a T to A (TAT to TAA) mutation that results in a premature stop codon (Y139STOP) in exon 4. Western blot analysis confirmed the absence of protein expression in platelet extracts from homozygous mutant mice. (J:169366)