通过Cre介导的重组,Is(2)46Ddu和Tn(sb-SBlac)C.176599bFsp之间的重组产生了一个300kb的缺失。这个缺失包含了Lnp上游基因沙漠的近端部分,但不包括调节Hoxd基因表达的全局控制区(GCR)。在E12.5时,发育中的趾端的Hoxd13和Hoxd12 mRNA表达量减少了70%于野生型水平。(来源:J:178930)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
Insertion, Intergenic deletion
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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