一个含假基因的neo cassette替换了1323到2845氨基酸序列,导致删除了几乎所有20AAR域,产生的蛋白质在1322位被截断(1322T)。通过Cre介导的重组,去除了插入在修改第15号外显子下游的floxed neo cassette(来源:J:180275)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
17
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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