构建了一个靶向载体,通过同源重组在ES细胞中将Cre/ERT2编码序列、poly(A)信号和Frt标记的neo选择座插入Notch 4的起始密码子附近。这导致了exon 1的大部分被删除。随后,杂合雄性与Flpe表达的雌性杂交,以去除选择座。(来源:J:179632)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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