通过同源重组,一个由LoxP和FRT介导的诺卡因抗性基因座替换了位于Kdr基因启动子上游27kb的远端多能间充质增强子(DMME)。Cre介导的重组去除了诺卡因基因座。定量RT-PCR和免疫组化分析显示,到了E7.5时,纯合胚胎中表达水平有所降低。(来源:J:178675)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
基因内删除
--
--
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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