在原目标等位基因中,包含一个无启动子的lacZ基因和一个被Cre切割去除的原floxed PGK-抗氨苄青霉素抗性基因的构建被实现了。在脑和睾丸的提取物中,Northern blot分析显示纯合突变小鼠中没有转录本。 Western blot分析证实了脑匀浆中编码蛋白的缺失。插入的lacZ基因表达受内源性启动子控制。(文献来源:J:59025, J:180429)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
未定义
--
1
1
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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