RMCE(重组介导的 cassette exchange)将一个带有核定位信号的完整lacZ基因插入到Nkx2-2tm1Suss中,取代了原有的 cassette。原等位基因中去掉了exons 1和2。lacZ的表达再现了内源基因的表达模式。(引用文献: J:178173, J:187468)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count