在Vmp1基因的12号外显子3'端和Mir21序列的5'端插入了loxP位点。接着是FRT引导的PGK-puro/deltaTK选择座,后面跟着另一个loxP位点。Mir21和选择座随后通过与Tg(EIIa-cre)C5379Lmgd纯合小鼠杂交来去除。Northern blot和PCR结果显示MIR21已不存在。(来源:J:179235)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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