Tg(Oxr1-cre)C14Stl

The cre recombinase sequence was inserted by BAC recombineering methods into the translation initiation site in exon 2 of the Oxr1 gene in a BAC construct which contained the promoter region, coding sequence and a 50 kb 3' downstream region. The final vector was injected into pronuclei of fertilized C57BL/6 eggs. 16 founders were obtained and crossed with lacZ reporter mice to identify one line which displayed robust recombination in superficial layer III the dorsal portion of the medial entorhinal cortex. (J:178297)