RMCE(重组介导的 cassette exchange)将Nkx2-2tm1Suss插入的核苷酸变异转化为tinman(TN)域的多个氨基酸替换(从TGFSVKDILDLP变为了TGFAAAAIVDLP)。一个FRT标记的neo cassette通过flp介导的重组被移除。(来源:J:177838)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion, Nucleotide substitutions
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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