在exon 1上游插入了一个loxP位点。接着在exon 3后面插入了一个3'有FRT标记的neo cassette,它自身带有loxP位点。通过Flp介导的重组,neo cassette被移除,导致exons 1到3都被留下了loxP标记的内含子。(来源:J:177412)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count