克隆的cDNA被插入到一个由小鼠Plp1基因的exon 1和内含子1组成的Plp1启动子元件中。转基因构建被微注射到囊胚的1细胞阶段。6/29个杂交瘤系阳性表达该转基因,其中2个杂交瘤系成功传代至下一代。RT-PCR结果显示,Line F633在P4和P28时仅在脊髓、脑干和大脑皮层中表达。(来源:172435)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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插入
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
IF
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