Cplane1^b2b012Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to C substitution at coding nucleotide 757 in exon 8 of the cDNA (c.757T>C, NM_001162906). This changes the serine residue to proline at position 253 of the encoded protein (p.S253P). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Cplane1b2b012Clo, and may be present in stocks carrying this mutation.