"破伤风毒素A基因和一个带有fluorocysteine标记的hygro序列替换了HS7(一个特异性的神经转录增强子)。通过Cre介导的重组,删除了floxed选择性 cassette。对整个大脑和小脑的RT-PCR分析显示,簇中所有基因的转录表达适度降低。然而,皮层、海马和嗅球的表达不受影响。(来源:177466)"

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129
Targeted
插入,基因内删除
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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