将一个puromycin-deltaTK(截短的胸苷激酶)序列通过同源重组插入V6.5 ES细胞的Sox2位点,使得TK受到内源性调控元件的控制。在产生的小鼠品系中,接触gancyclovir(GCV)会导致Sox2阳性(表达TK的)分裂细胞死亡。(来源:J:177655)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
--
1
6
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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