将一个puromycin-deltaTK(截短的胸苷激酶)序列通过同源重组插入V6.5 ES细胞的Sox2位点,使得TK受到内源性调控元件的控制。在产生的小鼠品系中,接触gancyclovir(GCV)会导致Sox2阳性(表达TK的)分裂细胞死亡。(来源:J:177655)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count