Lrrk2^tm1.1Npa

Exon 41 was replaced with a floxed modified exon 41 with nucleotide substitutions (GGG to TCG) that result in the amino acid substitution of serine for glycine at position 2019 (G2019S), mimicking a mutation found in some late-onset autosomal dominant Parkinson's Disease patients. An FRT-flanked neo cassette inserted downstream of the modified exon 41 was removed by flp-mediated recombination. The predicted protein is kinase enhanced. (J:176679)