Tg(tetO-APPSwInd)Dbo

The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2. Lines 18, 102, 107, and 885 were established. When mice are crossed with a line expressing a tTA transgene, these mice show the greatest doxycycline sensitivity for transgene suppression. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:80782, J:109829)