转基因包含来自CEPH Whole Genome MegaYAC Library的酵母人工染色体(YAC),它带有大约570kb的人类染色体21的DNA片段,其中包括钾向内整流通道亚家族J成员6基因,即KCNJ6(又称GIRK2,KIR3.2或HUM21ES123),在人类和携带YAC作为转基因的老鼠的脑中都能表达。经定量PCR分析,第57行显示该YAC携有两个拷贝(J:128897)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB
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插入
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4
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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