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中文
这个转基因包含了人类α-synuclein的cDNA，编码一个阿尔茨海默病相关突变的蛋白（A53T），由四环素响应性启动子控制。这种突变的α-synuclein仅在含有第二转基因表达的四环素转录激活器(tTA)时才表达。通过给予多西环素，可以抑制tTA与tetO的结合，从而抑制α-synuclein的表达。（来源：J:156801）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
