这个转基因包含了人类野生型α-synuclein的cDNA,由四环素响应性启动子驱动。只有在同时存在四环素转录激活因子(tTA),来自第二个转基因表达时,α-synuclein才会被表达。通过给予多西环素,可以抑制tTA与tetO的结合,从而抑制α-synuclein的表达。(来源:J:156801)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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Year
IF
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