IgH 3'增强子(通常位于启动子170kb外),带有敲除neo cassette,被插入到未翻译区下游。这个插入模拟了人类滤泡B细胞淋巴瘤中与t(14;18)染色体易位相关的特征。通过Cre介导的重组,neo cassette被剔除了。蛋白表达增加了3.5到5.5倍。(来源:J:175730)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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