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中文
在exon 1上游插入了loxP位点，通过同源重组在exon 2下游288bp处插入了含floxed neo cassette的片段。通过Cre介导的重组，删除了exons 1和2，包括内含子1和部分内含子2。免疫组化分析在E11.5期同源纯合胚胎的中脑背侧区域证实了野生型蛋白表达的缺失。(来源：J:175535)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
