Acox1^lampe1

An ENU induced mutation created a new splice site in intron 11-12 resulting in skipping of exon 12 and inclusion of 25 bps of intronic sequence and a premature stop codon at amino acid 618. Immunoblot analysis confirmed the expression of a mutant protein in the kidneys that has lower molecular weight, consistent with a 48 amino acid deletion. (J:174942)