在Myh9基因的第二个外显子5'端插入了增强绿色荧光蛋白(EGFP)的cDNA,同时在第二个内含子中插入了PGK-neor元件。通过Cre重组酶介导的剔除,选择性 cassette 已被消除。免疫印迹分析显示,杂合突变小鼠肺部野生型和带有EGFP标签的MYH9蛋白水平相当。(来源:J:175367)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
半显性
1
9
11

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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