设计了一种靶向载体,它在Sema5b靶向基因的第二个外显子上游插入了loxP位点,接着是含frt标签的诺卡因抗性(neo)基因座,后面跟着另一个loxP位点,位于第二个外显子下游。通过Cre介导的重组,去除了第二外显子和neo基因座。(来源:J:174679)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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