构建了一个靶向载体,包含xre/ERT2序列,受控于小鼠Dlx1/2(distal-less homeobox 1和2)基因,远端相似盒1/2,前脑增强子/启动子,I12b,内源性核糖体进入序列(IRES)后面跟着人类胎盘碱性磷酸酶基因(ALPP),以及SV40polyadenylation位点序列。这个载体被注入了FVB/N的供体卵子中,随后建立了Founder line 37(来源:J:134330)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
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7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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