插入了Velocigene cassette ZEN-Ub1导致了11号染色体(Build GRCm39)上4,615,1630-4,618,2453位置之间30,824bp的缺失。lacZ cassette替换了2-5号外显子。实时定量PCR确认了异种体大脑( hippocampus 和 cortex)中转录表达减少了50%。(文献引用:J:136110, J:219363)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
2
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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