插入了Velocigene cassette ZEN-Ub1导致了11号染色体(Build GRCm39)上4,615,1630-4,618,2453位置之间30,824bp的缺失。lacZ cassette替换了2-5号外显子。实时定量PCR确认了异种体大脑( hippocampus 和 cortex)中转录表达减少了50%。(文献引用:J:136110, J:219363)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count