Recombinase-mediated cassette exchange (RMCE) replaced the expression cassette between the JT15 and lox2272 sites of Gt(ROSA)26Sortm1Maoh with (5' to 3') an IRES, lacZ, polyadenylation sequence, CAG promoter, hygro gene, polyadenylation sequence, FRT site, polyadenylation sequence, and CAG driven tdTomato. Flp-mediated recombination removes all but the CAG promoter dtTomato reporter construct flanked by an FRT site and the lox2272 site. (J:173808)