RMCE替换了Gt(ROSA)26Sortm1Dwir中的floxed luciferase基因,用SV40 T-Ag病毒J区的73热休克蛋白捕获N端倒置融合蛋白(cT77)取代。融合蛋白包含108个卵白素片段(246-353,第258位由异亮氨酸替换为缬氨酸),带有经过验证的Kb和Ad/b的结合位点(专一性识别OT-I或OT-II/D011 TCR),以及eGFP报告基因。实现融合蛋白表达需要通过Cre介导的重组。(来源:J:173806)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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