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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Mgl2/Clec10a
tm1.1Cfg
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基础信息
表型特征
文献报道
在Mgl2基因的第二个外显子上游插入了一个含诺美西林抗性基因和一个5'的loxP位点的FRT引导选择载体,同时在Clec10a基因的第10个外显子下游插入了另一个loxP位点。随后,通过与携带Tg(EIIa-cre)C5379Lmgd转基因小鼠杂交,对目标位置的Mgl2基因的选择 cassette以及从第2到第10号外显子,以及Clec10a基因的全部序列,从这些经过定向改造的鼠中得以去除。(来源:J:94077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
5052341
B6.Cg-Thy1a
Targeted
Insertion, Intergenic deletion
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1
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1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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