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中文
构建了一个靶向载体，包含nls-cre重组酶序列连接到Ptgds基因的exon 1，以及位于crepoly A序列3'端的带有荧光素标记的hygromycin选择标记。在ES细胞中进行了同源重组，用靶向载体替换exon 1。随后，这些转基因小鼠杂交至FVB/N品系。通过后代与Tg(EIIa-cre)C5379Lmgd删除线杂交，去除floxed选择标记。同时，EIIa基因从背景中纯化出来。(来源：J:173718)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
