同源重组在Hbb-bh0和Hbb-bh1基因之间的基因组DNA片段被一个由诺卡因抗性基因座环绕的loxP序列所替换。替换的DNA段从ε-yglobin转录起始点下游7500bp延伸到8231bp(731bp)。随后,通过与Tg(CMV-cre)1Cgn转基因小鼠杂交,可选择性标记被去除了。(来源:J:173283)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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