同源重组在Hbb-bh0和Hbb-bh1基因之间的基因组DNA片段被一个由诺卡因抗性基因座环绕的loxP序列所替换。替换的DNA段从ε-yglobin转录起始点下游7500bp延伸到8231bp(731bp)。随后,通过与Tg(CMV-cre)1Cgn转基因小鼠杂交,可选择性标记被去除了。(来源:J:173283)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count