Tg(Tph2-icre/ERT2)6Gloss

The mouse bacterial artificial chromosome (BAC) RP23-151J17 containing Tph2, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, gene, was modified by insertion of sequence encoding iCreER at the Tph2 translation initiation ATG, and addition of a Kozak sequence upstream of the ATG. This BAC also contains the following genes: Tbc1d15, (TBC1 domain family, member 15 ), and AK048828. The modified BAC was used to generate the TPH2-iCreER transgene, which was microinjected into C57BL/6NTac fertilized eggs. Founder line 6 was subsequently established. (J:173677)