外显子2被替换成一个新基因座。在杂合子小鼠大脑匀浆的 Western blot 检测中,没有蛋白质表达,这通过蛋白水平减少了52%得到了确认(来源:J:172531)
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Exon 2 was replaced with a neo cassette. The absence of protein expression was confirmed by a 52% reduction in protein levels in a western blot brain lysate from heterozygous mice. (J:172531)