Notch1^tm4(cre)Rko

The Notch1 intracellular domain (IC) is replaced by the cre recombinase sequence and includes the SV40 3' UTR polyA signal while introducing a single nucleotide variation (SNV) at C5178A to facilitate genotyping. This allele does not have the 6xMyc tag present in the Notch1tm3(cre)Rko allele, and displays enhanced activity relative to that allele. (J:171829, J:172930)