设计了一种靶向载体,它包含一个由loxP序列引导的、随后是诺福韦(neo)抗性基因座的弗里特(frt)靶向序列,该基因座位于磷脂酰肌醇-4-激酶催化亚基(alpha polypeptide, Pi4ka)基因的第46外显子上游,以及第52外显子下游的另一个loxP序列。通过Flp介导的重组,去除了neo基因座。(来源:J:172497)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入
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1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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